Effect of Chronic Altitude Hypoxia on Redox Balance in Preadolescents and Adolescents

DOI:  https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10247

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Published: Oct 18, 2022
Issue: Vol. 20 No. 3 (2022): Ciencias de la Salud
Section Clinical or Experimental Research


Keywords: Oxidative stress hypoxia altitude children adolescents redox balance

Main Article Content

Authors

  Diana Marcela Ramos-Caballero
Departamento de Biología, Facultad de Ciencias, Universidad Nacional de Colombia (Bogotá); Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario (Colombia)
Pilar Rodríguez-Rodríguez
Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid (Spain)
Erica Mancera-Soto
Departamento del Movimiento Corporal Humano, Facultad de Medicina, Universidad Nacional de Colombia (Bogotá).
  Sandra Martins
Faculdade de Medicina, Universidade do Porto (Portugal)
Silvia M. Arribas
Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario (Colombia).
José Magalhães
Centro de Investigação em Atividade Física e Saúde (ciafel), Laboratório de Metabolismo e Exercício (LaMetEx), Faculdade de Desporto (fadeup), Universidade do Porto (Portugal).
Edgar Cristancho-Mejía
Departamento de Biología, Facultad de Ciencias, Universidad Nacional de Colombia (Bogotá).

Abstract

Introduction: Living at high altitude increases oxidative stress. Likewise, growth and maturation during adolescence can increase levels of reactive oxygen species (ROS). Changes in redox profiles have been evaluated in adults living at high altitudes; however, there are no studies on these changes in peripubertal populations living at moderate altitudes, we determine how living at moderate altitude affects the oxidative and inflammatory status of healthy preadolescents and adolescents. Materials and Methods: A cross-sectional study was conducted in healthy male Colombian preadolescents and adolescents (9–18 years old, Tanner scale classification) who lived at low altitude (n = 26) or moderate altitude (n = 26). Plasma oxidative and inflammatory status was assessed via spectrophotometry. Oxidative markers included malondialdehyde, 4-hydroxy-trans-2-nonenal, and carbonyl groups. Antioxidant markers included total antioxidant status, glutathione, catalase, superoxide dismutase, uric acid, and thiols. Inflammatory markers included interleukins-1, -6, and -10 and tumor necrosis factor. Results: Only uric acid levels were higher in adolescents (5.34 and 5.66 mg/dl) compared to preadolescents (3.85 and 4.07 mg/dl) in both moderate and low altitude groups, respectively. Participants who lived at moderate altitude presented significantly higher levels of malondialdehyde (4.82 and 3.73 nM/mg protein) and lower level of glutathione and thiols (1.21 and 1.26 μmol/mg protein) than in those at low altitude. Their inflammatory profiles did not differ. Conclusion: Oxidant profiles increased in peripubertal populations residing at moderate altitude; this could be owing to antioxidant consumption by ROS and active metabolism during puberty.

How to Cite
Ramos-Caballero, D. M., Rodríguez-Rodríguez, P. ., Mancera-Soto, E., Martins, S., Arribas, S. M., Magalhães, J., & Cristancho-Mejía, E. (2022). Effect of Chronic Altitude Hypoxia on Redox Balance in Preadolescents and Adolescents. Revista Ciencias De La Salud, 20(3). https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10247
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