Periventricular Nodular Heterotopia, Surgical Goal in Drug-Resistant Epilepsy

DOI:  https://doi.org/10.12804/revsalud12.03.2014.10

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Published: Sep 26, 2014
Issue: Vol. 12 No. 3 (2014)
Section Case Study


Keywords: Cortical Malformations Neuronal Migration Disorders Nodular Periventricular Heterotopia Drug-Resistant Epilepsy Epilepsy Surgery Neuropathology.

Main Article Content

Authors

Fernando Velandia-Hurtado
César Augusto Buitrago-Guzmán
Yésika Alexandra Fernández-Núñez
Carlos Mario Echeverría-Palacio

Abstract

Introduction: Neuronal heterotopia is a migration disorder in which these cells do not complete their movement toward the cerebral cortex. Periventricular nodular heterotopia is the most frequently reported form, characterized by neuronal conglomerates adjacent to the lateral ventricles walls. About 90 % of patients with this condition suffer epilepsy at some point in their lives and the major proportion of them will be resistant to pharmacologic treatment. This makes an appropriate diagnostic approach necessary in order to determine which patients would benefit from surgical resection of the lesion, which in most cases offers a high rate of crisis control. Development: This article presents a review of the most important topics approached from the practice of periventricular nodular heterotopia pathophysiology, clinical features, diagnosis and therapy. It is aimed at exploring the role of this condition as a cause of intractable epilepsy. Conclusion: Pharmacologic treatment for resistant epilepsy will have a severe impact on patient’s quality of life. Periventricular nodular heterotopia is frequently associated to this condition, which must be successfully approached by the medical team attempting to an opportune diagnosis and defining which patients would benefit from surgical management. This positively impacts the quality of life of these patients and their caregivers. 

Author Biographies

Fernando Velandia-Hurtado

Grupo de Investigación en Neurociencia, Neuros. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá,
Colombia.

César Augusto Buitrago-Guzmán

Unidad de Estudio y Tratamiento Integral de las Epilepsias (Uniepilepsias). Clínica Palermo. Bogotá, Colombia.

Yésika Alexandra Fernández-Núñez

Grupo de Investigación en Neurociencia, Neuros. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá,
Colombia.

Carlos Mario Echeverría-Palacio

Residente del programa de especialidad en Neuropediatría. Universidad Nacional de Colombia. Bogotá – Colombia.
How to Cite
Velandia-Hurtado, F., Buitrago-Guzmán, C. A., Fernández-Núñez, Y. A., & Echeverría-Palacio, C. M. (2014). Periventricular Nodular Heterotopia, Surgical Goal in Drug-Resistant Epilepsy. Revista Ciencias De La Salud, 12(3), 423–434. https://doi.org/10.12804/revsalud12.03.2014.10
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