Heterotopia Nodular Periventricular, objetivo cirúrgico em epilepsia refratária ao manejo farmacológico

DOI:  https://doi.org/10.12804/revsalud12.03.2014.10

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Publicado: sept 26, 2014
Edição: v. 12 n. 3 (2014)
Seção Presentación de caso


Palavras-chave: Malformacoes corticais desordens da migracao neuronal heterotopia nodular periventricular epilepsia refrataria cirurgia de epilepsia neuropatologia.

Conteúdo do artigo principal

Autores

Fernando Velandia-Hurtado
César Augusto Buitrago-Guzmán
Yésika Alexandra Fernández-Núñez
Carlos Mario Echeverría-Palacio

Resumo

Introdução: A heterotopia neuronal e um defeito da migracao no qual estas celulas nao completam seu deslocamento ao cortex. A forma mais comunmente reportada e a heterotopia nodular periventricular, caracterizada por conglomerados neuronais que se localizam adjacentes as paredes dos ventriculos laterais. Ate o 90% dos pacientes com esta condicao apresentam epilepsia em algum momento da vida e uma grande proporcao deles, serao refratarios ao manejo farmacologico. Isto faz necessaria uma adequada abordagem diagnostica, buscando estabelecer quais pacientes se beneficiariam de resseccao cirurgica da lesao, que na maioria dos casos oferece uma alta taxa de controle de crises. Desenvolvimento: Se apresenta um recorrido desde a pratica pelos aspectos com maior relevancia em quanto a fisiopatologia, manifestacoes clinicas, abordagem diagnostica e terapéutica da heterotopia nodular periventricular. Com o fim de explorar o rol desta condicao como causador de epilepsia refrataria. Conclusão: A epilepsia refrataria ao tratamento condiciona de maneira significativa a qualidade de vida dos pacientes. Uma entidade frequentemente associada a isto e a heterotopia nodular periventricular, a qual deve ser corretamente abordada pela equipe medica tratante procurando um diagnostico oportuno e definindo quais pacientes se beneficiam de manejo cirurgico. Desta forma impacta-se positivamente a qualidade de vida destes sujeitos e de seus cuidadores. 

Biografia do Autor

Fernando Velandia-Hurtado

Grupo de Investigación en Neurociencia, Neuros. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá,
Colombia.

César Augusto Buitrago-Guzmán

Unidad de Estudio y Tratamiento Integral de las Epilepsias (Uniepilepsias). Clínica Palermo. Bogotá, Colombia.

Yésika Alexandra Fernández-Núñez

Grupo de Investigación en Neurociencia, Neuros. Escuela de Medicina y Ciencias de la Salud. Universidad del Rosario. Bogotá,
Colombia.

Carlos Mario Echeverría-Palacio

Residente del programa de especialidad en Neuropediatría. Universidad Nacional de Colombia. Bogotá – Colombia.
Como Citar
Velandia-Hurtado, F., Buitrago-Guzmán, C. A., Fernández-Núñez, Y. A., & Echeverría-Palacio, C. M. (2014). Heterotopia Nodular Periventricular, objetivo cirúrgico em epilepsia refratária ao manejo farmacológico. Revista Ciencias De La Salud, 12(3), 423–434. https://doi.org/10.12804/revsalud12.03.2014.10
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