Stomatology and Systemic Management of Pemphigus Vulgaris: A Case Report

DOI:  https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.6774

Article Sidebar

PDF (Español (España)) HTML (Español (España)) Lector Inteligente (Español (España)) ePub (Español (España))

Published: May 24, 2018
Issue: Vol. 16 No. 2 (2018): Ciencias de la Salud
Section Case Study


Keywords: pemphigus corticosteroids dermatology oral medicine.

Main Article Content

Authors

Martha Carmona Lorduy
Grupo de Investigación GITOUC, Departamento de Medicina Oral, Facultad de Odontología, Universidad de Cartagena.
Iván Porto Puerta
Grupo de Investigación GITOUC, Facultad de Odontología, Universidad de Cartagena.
Sofía Berrocal Torres
Grupo de Investigación GITOUC, Facultad de Odontología, Universidad de Cartagena.
Francisco Camacho Chaljub
Departamento de Dermatología, Facultad de Medicina , Universidad de Cartagena.

Abstract

Introduction: Pemphigus vulgaris is a rare autoimmune disease of the skin and mucous membranes, its etiology is unknown and has a high mortality rate. The manifestations of this pathology are common in the oral cavity, so the dentist has a great responsibility in making a timely diagnosis, thus improving the prognosis. Case Presentation: A 63-year-old female patient with a pemphigus vulgaris diagnosis and lesions in the oral cavity and skin. The treatment was performed in teamwork between the departments of stomatology and dermatology. The systemic management was with prednisolone in high doses that diminished in determined periods of time; also immunosuppressive, antihistaminic, antibiotics and antimycotics medication was conducted. To treat lesions in the oral cavity, a master formula composed of hydrocortisone, vitamins A and E, low molecular weight glycerin and xylocaine in Orabase were applied to the lesions. The treatment was carried out for four months, after the first week, the resolution of the symptomatology in the oral cavity and skin was achieved; complete healing of all lesions was reached and no relapse was recorded after completion of treatment. Conclusion: The literature agrees that prednisolone is the drug of choice to treat this condition, it is found that a timely diagnosis would avoid the use of these drugs in high doses and for long periods of time, thus avoiding adverse reactions. The use of the master formula for lesions in the oral cavity is not reported in the literature and therefore its disclosure is considered important.

 

How to Cite
Carmona Lorduy, M., Porto Puerta, I., Berrocal Torres, S., & Camacho Chaljub, F. (2018). Stomatology and Systemic Management of Pemphigus Vulgaris: A Case Report. Revista Ciencias De La Salud, 16(2), 355–364. https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.6774
References

Bianciotto C, Herreras J, Álvarez M, Méndez M. Conjunctival blistering associated with Pemphigus Vulgaris: Report of a case. Arch Soc Esp Oftalmol. 2005;80(6):365-8.

Santoro F, Stoopler E, Werth, V. Pemphigus. Dent Clin North Am. 2013;57(4):597-610

De Oliveira M, Bisinelli J, Denis W. Pemphigus Vulgaris - Clinical Manifestation and Diagnosis. Oral Surg, Oral Med, Oral Path and Oral Rad. 2017;123(2):39-45.

Rossi C, Terrilli V, Rivero A, Chinchilla D, Bourren, P, Rodríguez E. Virus herpes en paciente con pénfigo vulgar. Arch. Argent. Dermatol. 2014;64(1):25-9.

Marchena L, Sánchez M, Osorio M. Manejo odontológico del pén go vulgar: caso clínico. J Dent. 2011;1(4): 158-161

Valencia O, Velásquez M. Inmunopatogenia del pén go vulgar y el pén go foliáceo. Iatreia. 2012;24(3):272.

Hertl M, Jedlickova H, Karpati S, Marinovic B, Uzun S, Yayli S. Pemphigus. S2 guideline for diagnosis and treatment –guided by the European Dermatology Forum (edf) in cooperation with the European Academy of Dermatology and Venereology (eadv). J Eur Acad Dermatol Venereol. 2015;29:405-14.

Rahbar Z, Daneshpazhooh M, Mirshams-Shahshahani M, Pemphigus disease activity measurments pemphigus disease area index, autoimmune bullous skin disorder intensity score, and pemphigus vulgaris activity score. J Am Acad Dermatol. 2014;150(3):266-72.

Nunes R, Moresco V, Marley, G, Silva B, Matesanz P. Pénfigo vulgar: Caso clínico. Av. Odontoestomatol. 2005;21(4): 189-193

Salgado A. Pénfigo vulgar localizado: presentación atípica del pénfigo vulgar. Reporte de caso. CES Medicina. 2010;24(2):99-103

Herrera I, Miranda J. Pénfigo vulgar: criterios actuales. Rev. Haba. Cien. Med. 2009;8(5):45-51

Lamey P. Rees T, Binnie W, Wright J, Rankin K, Simpson N. Oral presentation of penphigus vulgaris and its response to systemic steroid therapy. Oral Surg Oral Med Oral Pathol. 1992;74(1):54-7.

Hams-Davatchi C, Mortazavizadeh A, Daneshpazhooh M, Davatchi F, Balighi K, Esmaili N, et al. Randomized double blind trial of prednisolone and azathioprine, vs. Prednisolone and placebo, in the treatment of pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2013;27(10):1285-92.

Kanwar A, Vinay K, Sawatkar G, Dogra S, Minz R, Shear N, et al. Clinical and immunological outcomes of high and low dose rituximab treatments in pemphigus patients: a randomized comparative observer blinded study. Br J Dermatol. 2014;170(6):1341-49.

Souza E, Aiello B, Dias E, Montenegro L. Manifestaciones bucales del pén go vulgar: consideraciones generales. Reporte de caso clínico. Acta Odontol Venez. 2012;50(2) (Articulo Electronico).

Hall R, Fairley J, Woodley D. A multicentre randomized trial of the treatment of patients with pemphigus vulgaris with in iximab and prednisone compared with prednisone alone. Br J Dermatol. 2015;172:760-8.

Ellebrecht CT, Payne AS. Setting the target for pemphigus vulgaris therapy. JCI Insight. 2017;2(5): 1-11.

Behzad M, M€obs C, Kneisel A. Combined treatment with immunoadsorption and rit- uximab leads to fast and prolonged clinical remission in di cult-to-treat pemphigus vulgaris. Br J Dermatol. 2013;166:844-52.

Kasuya A, Moriki M, Tatsuno K, Hirakawa S, Tokura Y. Clearance e cacy of autoantibod- ies in double ltration plasmapheresis for pemphigus foliaceus. Acta Derm Venereol. 2013;93(2):181-2.

Ranugha P, Kumari R, Kartha L, Parameswaran S, Thappa D. Therapeutic plasma exchange as a crisis option in severe pemphigus vulgaris. Indian J Dermatol Venereol Leprol. 2013;78:508-10.

Baican A, Chiorean R, Leucuta D, Baican C, Danescu S, Ciuce D, et al. Prediction of survival for patients with pemphigus vulgaris and pemphigus foliaceus: a retrospective cohort study. Orphanet J Rare Dis. 2015;10:48.

Camacho F, López P, Bermejo A. Pénfigo vulgar. Presentación de catorce casos y revisión de la literatura. Med Oral Patol Oral Cir Bucal. 2005;10:282-8.

Gharote H, Nair P, Kasetty S, Thomas S, Kulkarni A. Pemphigus vulgaris - a report of three cases. BMJ Case Reports. 2012;10(11): 1-6.

Pires CA, Viana V, Araújo F, Müller S, Oliveira M, Carneiro F. Evaluation of cases of pem- phigus vulgaris and pemphigus foliaceus from a reference service in Pará state, Brazil. An Bras Dermatol. 2014;89(4):556-61.

Gregoriou S, Efthymiou O, Stefanaki C, Rigopoulos D. Management of pemphigus vulgaris: challenges and solutions. Clin Cosmet Investig Dermatol. 2015;8:521-7.

Arpita R, Monica A, Venkatesh N, Atul S, Varun M. Oral Pemphigus Vulgaris: Case Report. Ethiop J Health Sci. 2015;25(4):367-72.

Query Statistics

Downloads

Download data is not yet available.
Publcation metrics

1541 852




 

Published articles are solely the authors’ responsibility and do not commit the Editorial Committee nor the Scientific Committee. The copyrights belong to the Revista Ciencias de la Salud, therefore, total or partial reproduction of the published material is forbidden, unless there is a previous authorization.

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.