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Introduction: It is important to have a good cardiovascular adaptation; sleep quality influences the autonomic system, affecting heart rate and blood pressure. The evidence about the relationship between both variables is still insufficient; its measurement is diverse, as are the results. The objective was to evaluate the association between sleep quality and cardiovascular adaptation in health sciences university students. Methods: Cross-sectional and analytical observational study, carried out on 106 students from the Faculty of a private university in Lima (Peru). The Pittsburgh Sleep Quality Index (PSQI) was applied to evaluate the sleep quality, the Ruffier-Dickson Test to assess the cardiovascular adaptation, the Alcohol Use Disorders Identification Test (AUDIT) to identify the risk of alcoholism, and the International Physical Activity Questionnaire (IPAQ) to determine the physical activity. Results: 75.5% of participants had poor sleep quality, and 26.4% had inefficient or poor cardiovascular adaptation. The prevalence of inefficient or poor cardiovascular adaptation in those with poor sleep quality was 1.66 times higher than the prevalence of inefficient or poor cardiovascular adaptation in those with good sleep quality, but this difference was not statistically significant (PR=1.66; p =0.321). Conclusions: No association was found between sleep quality and cardiovascular adaptation in health sciences university students.

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