Factors Associated with the Presence of Extended-Spectrum Beta-Lactamase-Producing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru

DOI:  https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.9255

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Published: Jun 19, 2020
Issue: Vol. 18 No. 2 (2020): Ciencias de la Salud
Section Clinical or Experimental Research


Keywords: Urinary tract infection beta-lactamase antibiotic resistance.

Main Article Content

Authors

Vania Remenik-Zarauz
Facultad de Medicina, Universidad de San Martin de Porres, Lima.
Cristian Diaz-Velez
Facultad de Medicina, Universidad César Vallejo.
Moisés Apolaya-Segura
Clínica Jesús del Norte, Complejo Hospitalario San Pablo and Universidad de San Martín de Porres, Facultad de Medicina, Centro de Investigación Epidemiología Clínica y Medicina Basada en Evidencia. Lima.

Abstract

Introduction: Urinary tract infections (UTIs) are the second most frequent reason for healthcare visits, and antibiotic resistance among gram-negative bacteria of the Enterobacteriaceae family has increased significantly worldwide. The emergence of microorganisms that produce extended-spectrum beta-lactamase (ESBL) is especially problematic. This study aims to identify factors associated with the presence of UTI caused by ESBL-producing pathogens. Material and methods: An analytical cross-sectional study was conducted, and the urine culture database from a private healthcare clinic was analyzed. Factors possibly associated with the appearance of UTIs due to ESBL-producing pathogens were analyzed, including sex, age, number of hospitalizations, and previous UTIs. Results: A total of 1405 positive urine cultures were studied, 85.48% of which belonged to women. The mean age of the subjects was 39.98 ± 24.51 years, 24.13% of whom were over 60 years old. Of these, 55.56% had been attended on an outpatient basis. Almost half (49.18%) of the cultures tested positive for ESBL-related UTI, 96.58% of which had not presented with a previous UTI. A statistically significant association was found between sex and the development of UTI caused by ESBL-producing microorganisms (p = 0.007), with the male sex having the highest association (prevalence ratio, 1.224; 95% confidence interval: 1.035–1.448). In addition, age, number of previous hospitalizations, and prior intensive care unit admissions also showed associations with UTI development. No association was found with the presence of previous UTIs. Conclusion: A high frequency of UTIs were ESBL-related, and the factors associated with ESBL-related UTIs were male sex, age >60, and previous hospitalizations.
How to Cite
Remenik-Zarauz, V., Diaz-Velez, C., & Apolaya-Segura, M. (2020). Factors Associated with the Presence of Extended-Spectrum Beta-Lactamase-Producing Pathogens in Urinary Tract Infections in a Private Clinic in Lima, Peru. Revista Ciencias De La Salud, 18(2), 1–11. https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.9255
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