Analgesic Effectiveness of Lysine Clonixinate Associated with Paracetamol in the Postoperative Treatment of Exodontias

DOI:  https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.7943

Article Sidebar

PDF (Español (España)) HTML (Español (España)) Lector Inteligente (Español (España)) ePub (Español (España))

Published: Jun 4, 2019
Issue: Vol. 17 No. 2 (2019): Ciencias de la Salud
Section Clinical or Experimental Research


Keywords: Paracetamol ibuprofen lysine clonixinate tooth extractions.

Main Article Content

Authors

Reyma Evelyn Bacilio Amaranto, DD
Universidad Peruana Cayetano Heredia.
Pablo Alejandro Millones Gómez, PhD
Universidad Alas Peruanas.

Abstract

Introduction: The use of analgesic therapies to control post-exodontia pain is very varied and depends on many factors. The study had two aims: to compare the analgesic effectiveness of paracetamol associated with lysine clonixinate and to compare it with monotherapies of paracetamol and ibuprofen in exodontias’ postoperative treatment. Materials and methods: The sample consisted of 39 patients randomized into three groups. The postoperative pain was measured using the Visual Analogue Scale (VAS), at 1h, 8h, and 24h after exodontia. Statistical analysis of the evolution of the three therapies was performed using Student’s t-test, anova and Tuckey’s test, with a level of significance of p <0.05. Results: The values obtained showed that the analgesic combination of paracetamol associated with clonixinate of lysine was more effective at 1h and 8h. At 24h, there were no differences in the three study groups. Conclusion: The analgesia of the combined therapy of paracetamol associated with clonixinate of lysine is superior to that produced by the standard dose of ibuprofen and paracetamol in the treatment of post-operation pain of simple extractions.
Author Biographies

Reyma Evelyn Bacilio Amaranto, DD, Universidad Peruana Cayetano Heredia.

Universidad Peruana Cayetano Heredia.

Pablo Alejandro Millones Gómez, PhD, Universidad Alas Peruanas.

Universidad Alas Peruanas.
How to Cite
Bacilio Amaranto, DD, R. E., & Millones Gómez, PhD, P. A. (2019). Analgesic Effectiveness of Lysine Clonixinate Associated with Paracetamol in the Postoperative Treatment of Exodontias. Revista Ciencias De La Salud, 17(2), 321–333. https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.7943
References

Applebaum E, Nackley AG, Bair E, Maixner W, Khan AA. Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients. J Endod. 2015;41(8):1214-8. Doi: 10.1016/j.joen.2015.04.021

Fonseca Alonso B, Nixdorf DR, Shueb SS, John MT, Law AS, Durham J. Examining the Sensitivity and Specificity of 2 Screening Instruments: Odontogenic or Temporomandibular Disorder Pain? J Endod. 2017;43(1):36-45. Doi: 10.1016/j.joen.2016.10.001

Pozos AJ, Aguirre BG, Pérez UJ. Manejo clínico-farmacológico del dolor dental. ADM [internet]. 2008 [citado 2018 feb 12];65(1):36-43. Disponible en: https://www.medigraphic. com/pdfs/adm/od-2008/od081e.pdf

Pouchain EC, Costa FW, Bezerra TP, Soares EC. Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study. Int J Oral Maxillofac Surg. 2015;44(7):876-84. Doi: 10.1016/j.ijom.2014.10.026

Halling F, Heymann P, Ziebart T, Neff A. Analgesic prescribing patterns ofdental practitioners in Germany. J Craniomaxillofac Surg. 201;pii:S1010-5182(18)30531-6. Doi: 10.1016/j.jcms.2018.07.005

Groudine S, Fossum S. Use of intravenous acetaminophen in the treatment of postoperative pain. J Perianesth Nurs. 2011;26(2):74-80. Doi: 10.1016/j.jopan.2010.11.001 7. Renton T. Dental (Odontogenic) Pain. Reviews in Pain. 2011;5(1):2-7. Doi: 10.1177 /204946371100500102

Mariappan G, Saha BP, Sutharson L, Singh A, Garg S, Pandey L, et al. Analgesic, anti-inflammatory, antipyretic and toxicological evaluation of some newer 3-methyl pyrazolone derivatives. Saudi Pharm J. 2011;19(2):115-22. Doi: 10.1016/j.jsps.2011.01.003

Kulich RJ, Backstrom J, Brownstein J, Finkelman M, Dhadwal S, DiBennedetto D. A Model for Opioid Risk Stratification: Assessing the Psychosocial Components of Orofacial Pain. Oral Maxillofac Surg Clin North Am. 2016;28(3):261-73. Doi: 10.1016/j.coms.2016.03.006

Olmedo MV, Gálvez R, Vallecillo M. Double-blind parallel comparison of multiple doses of ketorolac, ketoprofen and placebo administered orally to patients with postoperative dental pain. Pain. 2001;90(1-2):135-41.

Benetello V, Sakamoto FC, Giglio FP, Sakai VT, Calvo AM, Modena KC, et al. The selective and non-selective cyclooxygenase inhibitors valdecoxib and piroxicam induce the same postoperative analgesia and control of trismus and swelling after lower third molar removal. Braz J Med Biol Res. 2007;40(8):1133-40.

Mehlisch DR. The efficacy of combination analgesic therapy in relieving dental pain. J Am Dent Assoc. 2002;133(7):861-71.

Breivik EK, Barkvoll P, Skovlund E. Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study. Clin Pharmacol Ther. 1999 66(6):625-35.

Au AH, Choi SW, Cheung CW, Leung YY. The Efficacy and Clinical Safety of Various Analgesic Combinations for Post-Operative Pain after Third Molar Surgery: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(6):e0127611.

Petrikas AZ, Iusufova MV, Chestnykh EV, Nechaeva AA, Zin’kovskaia EP. [Placebocontrolled study of analgesic activity of analgin, paracetamol and dexalgin byelectric pulp sensitivity testing]. Stomatologiia (Mosk). 2015;94(1):20-22. Doi: 10.17116/stomat201594120-22

Daniels SE, Atkinson HC, Stanescu I, Frampton C. Analgesic Efficacy of an Acetaminophen/ Ibuprofen Fixed-Dose Combination in Moderate to Severe Postoperative Dental Pain: A Randomized, Double-Blind, Parallel-Group,Placebo-Controlled Trial. Clin Ther. 2018 pii: S0149-2918(18)30382-5. Doi: 10.1016/j.clinthera.2018.08.019

Coppla FM, Rezende M, de Paula E, Farago PV, Loguercio AD, Kossatz S, et al. Combination of Acetaminophen/Codeine Analgesics Does Not Avoid Bleaching-Induced Tooth Sensitivity: A Randomized, Triple-Blind Two-Center Clinical Trial. OperçDent. 2018;43(2):E53-63. Doi: 10.2341/17-092-C

Noronha VR, Gurgel GD, Alves LC, Noman-Ferreira LC, Mendonça LL, Aguiar EG, et al. Analgesic efficacy of lysine clonixinate, paracetamol and dipyrone in lower third molar extraction: a randomized controlled trial. Med Oral Patol Oral Cir Bucal. 2009;14(8):e411-5.

Daniels SE, Goulder MA, Aspley S, Reader S. A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain. Pain. 2011;152(3):632-42. Doi: 10.1016/j.pain.2010.12.012

Pérez-Urizar J, Pozos-Guillén A, Martínez-Rider R, Torres-Roque I, Aguilera-Suárez G, Gómez-Sánchez M. Eficacia analgésica de la combinación de clonixinato de lisina y diclofenaco versus ibuprofeno o ketorolaco después de la extracción del tercer molar mandibular impactado. Estudio piloto. Revista ADM [internet] 2013 [citado 2018 mar 12];70(3):126-33. Disponible en: https://www.medigraphic.com/pdfs/adm/od-2013/ od133d.pdf

Perez-Urizar J, Martínez-Rider R, Torres-Roque I, Garrocho-Rangel A, Pozos-Guillen A. Analgesic efficacy of lysine clonixinate plus tramadol versus tramadol in multiple doses following impacted third molar surgery. Int J Oral Maxillofac Surg. 2014;43(3):348-54.

Declaración de Helsinki de la AMM. Principios éticos para las investigaciones médicas en seres humanos. Asociación médica mundial [internet]. 2013 [citado 2018 mar 14]. Disponible en: http://www.isciii.es/ISCIII/es/contenidos/fd-investigacion/fd-evaluacion/ fd-evaluacion-etica-investigacion/Declaracion-Helsinki-2013-Esp.pdf

Becker DE, Phero JC. Drug therapy in dental practice: nonopioid and opioid analgesics. Anesth Prog. 2005;52(4):140-9. Doi: 10.2344/0003-3006

Romero-Ruiz M, Herrero-Climent M, Torres-Lagares D, Gutiérrez-Pérez J. Protocolo de control del dolor y la inflamación postquirúrgica: Una aproximación racional. rcoe 2006;11(2):205-15. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1138-123X2006000200005

De Souza K, Guerzet A, Soares R, Souza L, Silveira P, Groppo F. Comparison between lysine and paracetamol for post tooth extraction pain control. Rev Dor 2012,13(4):356-9. Doi: http://dx.doi.org/10.1590/S1806-00132012000400009

Poveda RR, Bagán JV, Jiménez SY, Gallud RL. Use of nonsteroidal antiinflammatory drugs in dental practice: A review. Med Oral Patol Oral Cir Bucal. 2007;12(1):10-8. Available from: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1698-69462007000100004

González-Escalada J. La sinergia farmacológica aplicada a la analgesia: revisión de la combinación de ibuprofeno con codeína. Rev Soc Esp Dolor. 2010;17(1):51-60. Disponible en: http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1134-80462010000100007

Isiordia-Espinoza MA, de Jesús Pozos-Guillén A, Aragon-Martinez OH. Analgesic efficacy and safety of single-dose tramadol and non-steroidal anti-inflammatory drugs in operations on the third molars: a systematic review and meta-analysis. Br J Oral Maxillofac Surg. 2014 Nov;52(9):775-83. Doi: 10.1016/j.bjoms

Taggar T, Wu D, Khan AA. A Randomized Clinical Trial Comparing 2 Ibuprofen Formulations in Patients with Acute Odontogenic Pain. J Endod. 2017 May;43(5):674-8. Doi: 10.1016/j.joen.2016.12.017

Cooper S. Five studies on Ibuprofen for post-surgical dental pain. Am J Med. 1984;77(1):70-7.

Pozzi A, Gallelli L. Pain management for dentists: the role of ibuprofen. Ann Stomatol (Roma). 2011 2(3-4 Suppl):3-24. Available from: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3414241/

Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58(3): 621-81. Doi: 10.1124/pr.58.3.10

Barrera NP, Morales B, Torres S, Villalón M. Principles: mechanisms and modeling of synergism in cellular responses. Trends Pharmacol Sci. 2005;26(10):526-32. Doi: 10.1016/j. tips.2005.08.003

Merry AF, Gibbs RD, Edwards J, Ting GS, Frampton C, Davies E, et al. Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. Br J Anaesth. 2010;104(1):80-8. Doi: 10.1093/bja/aep338

Swierkosz TA, Jordan L, McBride M, McGough K, Devlin J, Botting RM. Actions of paracetamol on cyclooxygenases in tissue and cell homogenates of mouse and rabbit. Med Sci Monit. 2002;8(12):BR496-503. Available from: https://www.ncbi.nlm.nih.gov/ pubmed/12503027

Burian M, Geisslinger G. COX-dependent mechanisms involved in the antinociceptive action of NSAIDs at central and peripheral sites. Pharmacol Ther. 2005;107(2):139-54. Doi: 10.1016/j.pharmthera.2005.02.004

Bailey E, Worthington HV, van Wijk A, Yates JM, Coulthard P, Afzal Z. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev. 2013;12(12). Doi: 10.1038/sj.bdj.2014.330

Ferraiolo DM, Veitz-Keenan A. Ibuprofen is superior to paracetamol for pain relief following third molar removal. Evid Based Dent. 2014;15(4):106-7. Doi: 10.1038/sj.ebd.6401059

Cooper SA, Schachtel BP, Goldman E, Gelb S, Cohn P. Ibuprofen and acetaminophen in the relief of acute pain: a randomized, double-blind, placebo-controlled study. J Clin Pharmacol. 1989 Nov;29(11):1026-30. Available from: https://www.ncbi.nlm.nih.gov/ pubmed/2689471

Hersh EV, Levin LM, Cooper SA, Doyle G, Waksman J, Wedell D, Hong D, Secreto SA. Ibuprofen liquigel for oral surgery pain. Clin Ther. 2000 Nov;22(11):1306-18. Available from: https://www.ncbi.nlm.nih.gov/pubmed/11117655

Millones-Gómez P, Huamaní-Muñoz W. Efectividad de la antibioticoterapia en la reducción de la frecuencia de alveolitis seca postexodoncia simple. Ensayo clínico aleatorizado de grupos en paralelo, controlado y ciego simple, Rev Esp Cir Oral Maxilofac. 2016;38( 4):181-7. Doi: https://doi.org/10.1016/j.maxilo.2014.04.004

Query Statistics

Downloads

Download data is not yet available.
Publcation metrics

37987 1185




 

Published articles are solely the authors’ responsibility and do not commit the Editorial Committee nor the Scientific Committee. The copyrights belong to the Revista Ciencias de la Salud, therefore, total or partial reproduction of the published material is forbidden, unless there is a previous authorization.

Similar Articles

You may also start an advanced similarity search for this article.