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Introduction: The main goal of the present review was to systematically compile data on interventions to reduce stigma in Ibero-America. The aim is to describe the characteristics and determine the main results of interventions to reduce stigma towards people with severe mental disorders that have been developed in Latin America between the years 2007-2017. Materials and methods: A systematic review of articles from electronic databases such as MEDLINE, EBSCOHOST, EMBASE, LILACS and SCIELO, and grey literature obtained from Google Scholar, published in English, Spanish, and Portuguese covering the period between January 2007 and December 2017 was carried out. In order to evaluate the quality of the quantitative studies, ROBINS criteria were used for quasi-experimental and experimental studies, and CASPe criteria were used for qualitative studies. Results: A total of sixteen studies that met the inclusion criteria were selected; 75% were quantitative and out of these, one quarter did not meet the quality criteria. Conclusions: Currently, there are few interventions to reduce stigma in Ibero-America and they are mainly short term. Our evaluation of the available literature helps to identify aspects that should be included in future research in order to reduce possible biases that could arise when developing these types of studies.

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