Biocompatibility with the Ocular Surface and Antimicrobial Activity of a New Multi-Purpose Contact Lens Solution

DOI:  https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10178

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Published: Jan 27, 2021
Issue: Vol. 19 No. 1 (2021): Ciencias de la Salud
Section Clinical or Experimental Research


Keywords: soluciones multipropósito , lentes de contacto blandos , polihexametilen biguanida , hiperemia , tinción corneal , actividad antimicrobiana , unidades formadoras de colonias Multipurpose solution , soft contact lenses , polyhexamethylene biguanide , hyperemia , corneal staining , antimicrobial activity , colony forming units soluções multipropósito , lentes de contato macias , polihexametileno biguanida , hiperemia , coloração da córnea , atividade antimicrobiana , unidades formadoras de colônias

Main Article Content

Authors

Martha Fabiola Rodríguez
Universidad de La Salle
Ingrid Astrid Jiménez
The University of New South Wales
Laura Victoria Martín
Universidad de La Salle
Fernando Ballesteros
Universidad de La Salle

Abstract

Introduction: Multipurpose solutions (MPS) for soft contact lenses (SCL) play an essential role in inhibiting potentially pathogenic agents. Their antimicrobial effectiveness is assessed in vitro and their safety in vivo, with clinical trials that include a combination of different solutions and lens materials. The objective is to assess the biocompatibility of a new SCL MPS produced in Colombia that contains polyhexam-ethylene biguanide (PHMB) and to determine its antimicrobial activity. Materials and Methods: This was a crossover study with 25 subjects who did not wear lens and who were fitted with different combinations of five SCL materials with either MPS or control physiological saline solution (CS). Corneal thickness, conjunctival hyperemia, corneal staining, and comfort were assessed after two hours of wearing SCL. Antimicrobial effectiveness was measured using iso 14729 standard assays. Results: When considering SCL material, there was a statistically significant difference between the new MPS and the cs for Comfilcon A (p < 0.05). There was no statistical or clinically significant difference for corneal thickness or corneal staining between the combination of lens material and new MPS with the CS (p > 0.05). After two hours of lens insertion, comfort scores were higher than 7.8. The MPS reduced bacteria colony-forming units (CFU) in over 3 log, and fungal CFU in over 1.0 log. Conclusions: The new MPS met the antimicrobial standards of iso 14729, is considered safe and biocompatible with the ocular surface and retains high comfort levels.

How to Cite
Rodríguez, M. F., Jiménez, I. A., Martín, L. V., & Ballesteros, F. (2021). Biocompatibility with the Ocular Surface and Antimicrobial Activity of a New Multi-Purpose Contact Lens Solution. Revista Ciencias De La Salud, 19(1). https://doi.org/10.12804/revistas.urosario.edu.co/revsalud/a.10178
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