Animal model of cognitive decline and neural transplantation of Stem cells as a prospective therapy

Alcyr Alves de Oliveira, Leticia Bertuzzi, Patricia Santos da Silva, Élida Fluck Pereira Neto, Rafael Nicolaidis


There are few animal models of cognitive decline that could be considered as prominent as the cholinergic lesion model of Alzheimer's disease. Alzheimer's disease is a neurodegenerative disorder associated with aging with accentuated progressive cognitive impairment. Its multiple complex sequential and interactive neural pathways may lead to the understanding that single agent interventions might be insufficient to impact the course of this disease. The current pharmacological treatment is palliative and, although it may slow down the disease’s progression, it still cannot offer cure. The combination of drugs and antioxidant substances has been investigated, nevertheless there are few studies demonstrating optimal and consistent results based on this combination. Thus, the purpose of this paper is to highlight cell-based therapies as prospective treatment of peripheral and central nervous system disorders.

Palabras clave

Animal models of cognitive decline; Alzheimer's disease; Stem cell based therapy

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